5-HTP B6

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid that is produced from the essential amino acid tryptophan during the process of serotonin synthesis. 5-HTP is the immediate biochemical precursor of serotonin, a calming neurotransmitter associated with feelings of satisfaction, relaxation and general wellbeing.

Serotonin depletion is common in people with chronic stress and an inflamed physiology. Stress and inflammation divert tryptophan down an alternate pathway (known as the kynurenine pathway) which does not make 5-HTP, and produces kynurenine instead of serotonin as an end product. To drive the serotonin pathway, 5-HTP, the critical intermediary in serotonin synthesis, must be created or supplied.

Serotonin is best known as our feel-good, calming neurotransmitter. Serotonin also plays an important role in proper function of the brain-gut axis, a two-way system of communication between the central nervous system and the GI tract. Up to 95% of the body’s serotonin is located in the gut. Serotonin is also the precursor of melatonin, a neurotransmitter which helps maintain circadian rhythm and is required for healthy functioning of the sleep/wake cycle.

As a supplement, 5-HTP has been researched primarily for helping to support healthy mood and a healthy relaxation response. In addition, 5-HTP has been suggested to help promote improved appetite control, particularly in relation to sugar and carbohydrate cravings. 5-HTP also may help to support healthy digestive and intestinal barrier function, notably in people with irritable bowel syndrome.

5-HTP SELECT is a custom formulation combining 50 mg of 5-HTP with 10 mg of Pyridoxal-5′-Phosphate (P5P), the activated form of vitamin B6. P5P serves as a required cofactor in serotonin synthesis, supports healthy neurotransmitter metabolism overall and helps to promote the efficacy of this product.